The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone ...A stability indicating HPLC assay has been developed in order to investigate the effect of different factors on the stability of omeprazole. These factors included the pH with the tested values ranging from 6–10 and the temperature by monitoring the drug stability at 25, 37 and 40°C. The study was then extended to investigate the effect of ...Using the approach of Higuchi and Connors, phase-solubility studies were performed at increasing concentrations of the three CD. Fig. 2 shows that the solubility of CBD increased linearly with the concentrations of HPβCD and HPγCD which corresponds to the AL type profile (formation of 1:1 inclusion complexes). On the contrary, the phase ...The solubility method was carried out according to the method of Higuchi and Connors (Higuchi and Connors, 1965). The screw capped vials containing samples (10.0–70.0 mg) in excess amounts in aqueous β-CyD solutions (3.0 ml of 0.0–2.0×10 −2 M in 10 mM phosphate buffer, pH 7.4) were shaken at 37°C.PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir.Phase solubility of FA/HP-β-CD complex. Phase solubility studies were carried out according the method described by Higuchi and Connors’s methods (1965). Excess amounts of FA were added to 10 ml of water solution of HP-β-CDs at different concentrations ranging from 0 to 8.5 mM.Phase solubility study. The stoichiometry and the overall complex formation constant K 3 were measured according to Higuchi and Connors (experiment A). In addition the determination of the single complex formation constants (K 1 and K 2) were measured by a modified phase solubility (experiment B): (A) Experiment with different concentrations of ...2.3 Phase solubility studies. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). 21 Excess amounts of EO were added to CD solutions at different concentrations ranging from 0 to 40mM. The mixtures were shaken overnight at 25°C and then filtered through a 0.45 μm membrane filter.This article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained …The phase solubility studies were performed according to the method described by Higuchi and. Connors [24]. Different concentrations of β-CD and HPβ-CD were ...Phase solubility diagrams and their classification according to Higuchi and Connors. S0 is the intrinsic solubility of drugs in aqueous medium. Source publication. +4. …Solubility studies used deionized water, and 1 H NMR spectra were of solutions in deuterium oxide (D 2 O, deuterium content 99.8%) from Fluka (Barcelona, Spain). 2.2. Phase solubility studiesSolubility measurements were carried out according to the method of Higuchi and Connors (1965). Excess amounts of clofibrate were added to a series of ...Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117-212. 10. Asker AF, Whitworth CW. Dissolution of acetyl salicylic acid from acetyl salicylic acid-polyethylene glycol 6000 coprecipitates. Pharmazie 1975;30:530-1. ... T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 …The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending.Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...3.8. Solubility Studies. The phase-solubility profiles of the three polymorphic forms of benzocaine were determined according to the method of Higuchi and Connors , and were performed by using a Thermo Scientific™ MaxQ™ 4450 Benchtop Orbital Shaker (Thermo Scientific, Waltham, MA, USA). To 25.0 mL flasks, containing 10.0 mL methanol …Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.Phase-solubility techniques 来自 scienceopen.com 喜欢 0. 阅读量： 717. 作者： TK Higuchi ， A Connors.The phase solubility investigation was carried out according to Higuchi and Connors approach . Excess DoN was added to distilled water containing various concentrations of Kollidon VA 64 in 20-mL capped bottles, stirred for 48 h at 25 and °C on magnetic stirrer, filtered, and spectrophotometrically analyzed at 283 nm using a double …Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.Higuchi T, Connoras KA. Phase-solubility techniques, ADV Anal Chem Instrum, 1965, 4, 117-210. has been cited by the following article: Article. Solid Dispersion Incorporated Microcapsules: Predictive Tools for Improve the Half Life and Dissolution Rate of Pioglitazone Hydrochloride.One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review.Types of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.Higuchi T, Connors K (1965) Phase solubility techniques. In: Reilly CN (ed) Advances in analytical chemistry instrumentation. Interscience, New York, NY, pp 117–212. Google Scholar Jozefaciuk G, Muranyi A, Fenyvesi E (2001) Effect of cyclodextrins on surface and pore properties of soil clay minerals. Environ. Sci.Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ...Solubility studies. The phase-solubility diagram corresponding to DPS:βCD system is illustrated in Fig. 5. It was performed according to the method reported by of Higuchi and Connors in order to determine the stability constant of the suggested complex and evaluate its stoichiometry. Measurements were made at 291 nm, which …The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone ...Sep 1, 2010 · HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 ... 2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …The Higuchi and Connors 30 method was used to classify the phase-solubility profiles. The apparent stability constant ( K 1:1, eq 1 ) and the CE ( eq 2 ) were determined from the slope of the linear phase-solubility diagrams plots of the total drug solubility ([ D t ]) versus total concentration of CD in liquid phase ([CD liq ]) in moles per ...Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ...Jun 15, 2019 · Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ... The solubility of hydrocortisone (HC) was measured in water containing varying concentrations of γCD. The resulting B S-type phase-solubility diagram was described within the theoretical framework laid out by Higuchi and Connors. The initial linear increase in the solubility at low concentrations of γCD was caused by the …Phase solubility study. Classification of inclusion complex formation and stability of the inclusion compounds were evaluated by phase solubility study (Higuchi & Connors, 1965). An excess of black pepper oil was added to 10 mL aqueous solutions of HPβCD ranging in concentration from 0 to 10 mmol/L and incubated at 25 and 35 °C for …The phase solubility analysis described by Higuchi and Connors is the most widely used method to describe inclusion complexation (Brewster and Loftsson 2007; Challa et al. 2005). The excess insoluble drug is placed in vials with a constant volume of aqueous carrier containing several solutions with high concentrations of CD.Phase solubility of GO/β-CD complex. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Excess amounts of GO were added to 10 ml of water solution of β-CD at different concentrations ranging from 0 to 9.5 mM.All solubility measurements were performed six times. 2.2.2. Phase solubility study. Phase solubility study was performed according to the method described by Higuchi and Connors [17]. An excess amount of aceclofenac was placed in a 25 ml glass flask containing different concentrations of polymers in 20 ml distilled water.Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on a rotary shaker ...Derived from the slope of the linear phase solubility diagram, the apparent stability constant ... (25–100 mM), as described by Higuchi and Connors (1965). After shaking for 48 h at 37 °C ± 1 °C in a shaking water bath to reach equilibrium, samples were collected in triplicate and subsequently filtered through a 0.45 μm polyvinylidene ...Phase solubility diagrams and their classification according to Higuchi and Connors. S0 is the intrinsic solubility of drugs in aqueous medium. Source publication. +4. …Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; Chemistry[16] T. Higuchi, K. A. Connors, “Phase Solubility Techniques”, Advances in Analytical Chemistry and Instrumentation, 4, 117-150, 1965. [17] T. Higuchi, H. Kristiansen, “Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies”, Journal …Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation.Aug 8, 2022 · Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ... The plotted diagram displays a straight line with slopes less than 1, suggesting characteristic of Higuchi A L type. This indicate the formation of a 1:1 molecular ratio between the API and the CD. Using the Higuchi–Connors equation, the apparent solubility constant (K C) was determined from Fig. 1, resulting in a value of 122.01 M-1.Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ...7 May 2015 ... ... solubility method (Higuchi and Connors 1965). Figure 1 shows the phase ... Higuchi T, Connors KA (1965) Phase-solubility techniques. Adv Anal ...Higuchi T, Connors K (1965) Phase solubility techniques. In: Reilly CN (ed) Advances in analytical chemistry instrumentation. Interscience, New York, NY, pp 117–212. Google Scholar Jozefaciuk G, Muranyi A, Fenyvesi E (2001) Effect of cyclodextrins on surface and pore properties of soil clay minerals. Environ. Sci.The phase solubility investigation was carried out according to Higuchi and Connors approach . Excess DoN was added to distilled water containing various concentrations of Kollidon VA 64 in 20-mL capped bottles, stirred for 48 h at 25 and °C on magnetic stirrer, filtered, and spectrophotometrically analyzed at 283 nm using a double …The Higuchi and Connors 30 method was used to classify the phase-solubility profiles. The apparent stability constant ( K 1:1, eq 1 ) and the CE ( eq 2 ) were determined from the slope of the linear phase-solubility diagrams plots of the total drug solubility ([ D t ]) versus total concentration of CD in liquid phase ([CD liq ]) in moles per ...All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ...(3) (Higuchi and Connors, 1965). As mentioned pre- viously poorly soluble ... Phase-solubility techniques. Adv. Anal. Chem. Instrum. 4, 117–212. Johnson ...According to Higuchi and Connors’ theory, [17] the phase-solubility relationships between PD and β- and γ-CDs are classified as typical A L-type, ... according to the method reported by Higuchi and Connors (1965). ... Phase solubility techniques. Adv. Anal. Chem. Instrum., 4 (1965), pp. 117-212. View in Scopus Google ScholarPhase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP--CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP--CD ing different concentrations of HP--CD, ranging from 14.3 mM ...Phase solubility studies. Excess FLB (50 mg) was mixed with 5 mL of distilled water in closed stoppered test tubes containing different HP-β-CD concentrations (25–100 mM), as described by Higuchi and Connors (1965).Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google ScholarDec 15, 2014 · Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added. The apparent stability constant of the KET- BCD complex, assuming 1:1 stoichiometry, were calculated from the slope of the initial straight portion of the phase solubility diagrams as KH = slope/S0(1 - slope) where So is the solubility of the pure drug (Higuchi and Connors, 1965). All the data are the average of three determinations. 2.3.Higuchi T, Connors AK. Phase solubility techniques. In: Reilly CN, editor. Advances in Analytical Chemistry and. Instrumentation. New York: Wiley-Interscience; ...Phase Solubility Studies. The determination of the phase solubility diagram is a widely accepted method for evaluation of the effect of cyclodextrin complexation on the drug solubility. The phase solubility studies were performed by the method reported by Higuchi and Connors . Increasing concentrations of MβCD (0–0.23 M) or …PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir. There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117-212. 10. Asker AF, Whitworth CW. Dissolution of acetyl salicylic acid from acetyl salicylic acid-polyethylene glycol 6000 coprecipitates. Pharmazie 1975;30:530-1. ... T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 …J Chem Educ 78(11): pharmaceuticals. Boca Raton, Florida: Taylor and Francis 1499. Group, LLC. Higuchi T, Connors KA (1965) Phase-solubility techniques. ACD/ChemSketch (2009) Version 12.01. Adv Anal Chem Instrum 4: 117–212.Phase Solubility Analysis. C R C Critical Reviews in Analytical Chemistry: Vol. 1, No. 2, pp. 193-215. ... Takeru Higuchi . Pages 193-215 Published online: 18 Feb 2008.Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility.May 1, 2022 · All experiments were repeated three times. According to the linear part of the phase solubility curve, the stability constant (Kc) was calculated using the Higuchi-Connors equation. (1) K c = S l o p e S 0 × (1-S l o p e) S 0: the solubility of NAR without β-CD. The solubilizing efficiency of β-CD was evaluated by the complexation efficiency ... The K C and CE were calculated from the intrinsic solubility (S 0 ) in the complexing medium and the initial linear slope of the phase solubility diagram (Higuchi and Connors 1965;Loftsson et al ...Phase-solubility analysis Phase-solubility studies were performed using the method described by Higuchi and Connors [17]. A fixed amount of IDE exceeding its solubility, was added to unbuffered aqueous solutions of SBE-b-CD, (0.0–9.0 9 10-3 M) in 10 mL capped tubes, then sonicated in a Bandelin RK 514 water bath (Berlin, Germany) for 15 …... Higuchi-Connors phase solubility method. この論文は、ヒグチコンノル相溶解法 ... techniques including Fourier Transform Infrared Spectroscopy (FTIR) and ...T. Higuchi, A. Connors Published 1965 Chemistry No Paper Link Available Save to Library Create Alert Cite 2,644 Citations Citation Type More Filters Environmentally friendly stability-indicating HPLC method for the determination of isotretinoin in commercial products and solubility samplesAccording to the classification method of Higuchi and Connors (Chen et al., Citation 2007; Higuchi & Connors, Citation 1965), ... Phase-solubility techniques. Adv Chem Instrum 4:117–212 [Google Scholar] Joo JI, Kim DH, Choi JW, Yun JW. (2010). Proteomic analysis for antiobesity potential of capsaicin on white adipose tissue in rats fed with a high fat diet.Phase solubility analyses of F-Asta and Asta-E with HPβ-CD were performed following procedures similar to the ones reported previously (Higuchi & Connors, 1965; Schönbeck et al., 2017 ...where [D/CD] is the concentration of dissolved drug-cyclodextrin complex, [CD] is the concentration of dissolved free cyclodextrin and slope is the slope of the phase solubility profile (Higuchi, Connors, 1965 Higuchi T, Connors AK. Phase solubility techniques. In: Reilly CN, editor. Advances in Analytical Chemistry and Instrumentation.Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google Scholar The phase solubility curve can be classified as an A L-type diagram, according to the Higuchi and Connors classification (Higuchi and Connors, 1965). The slope of the solubility diagram (0.70) was lower than 1, indicating the formation of 1:1 (mol/mol) ACV-SBE-β-CD inclusion complex.To determine binding constants by Higuchi and Connors method, the acids solubility was determined by CZE after their agitation in the solutions of HP-γ-CD (with 0.6 molar substitution) at 25 °C for 3 days. The dependences of acids solubility on HP-γ-CD concentration deviated from straight line in the range of high concentration (A N mode ...Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, …The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl)-β-CyD (DIMEB), randomly methylated-β ... A 1:1 stoichiometry was proposed by the phase solubility studies both in presence and absence of PVP. The most plausibe mode of inclusion of arteether into the CD cavity is revealed by molecular modeling studies utalizing Fast Rigid Exhaustive Docking acronym.Grant DJW and Higuchi T. Solubility Behavior of Organic Compounds. Wiley, New York, NY, 1990. Google Scholar Higuchi T and Connors KA. Phase-Solubility Techniques. Advan Anal Chem Instr 1965; 4: 117–212. CAS Google Scholar Huang LF and Tong WQ. Types of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration.Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has …2 May 2011 ... It has to be noted that in the Higuchi and Connors method applied, Kc was obtained from the apparent cholesterol solubility, which comprises ...Higuchi, K.A. Connors, Phase solubility techniques Advances in Analytical Chemistry and Instrumentation 4: (1965) 127-212 4. F. Djedaïni, B. Perly, Nuclear Magnetic Resonance of cyclodextrin derivatives and inclusion compounds D. Duchene, New Trends in Cyclodextrins and Derivatives (1992) Editions de Santé Paris Ch. 6 5.Higuchi, K.A. Connors, Phase solubility techniques Advances in Analytical Chemistry and Instrumentat, Phase solubility study. Classification of inclusion complex formation and stability of , 11 Tem 2017 ... Higuchi T, Connors KA. Phase solubility techniques. Advances in Analytical Chemistry and Instrumen- ta, Solubility diagrams were obtained according to Higuchi and Connors (1965). Exces, Phase solubility of FA/HP-β-CD complex. Phase solubi, Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solu, Solubility method (phase solubility analysis) Solubility st, Higuchi T, Connoras KA. Phase-solubility techniques, ADV Anal Ch, Phase solubility measurements of SBE 7-β-CD and valsartan were, T. Higuchi and K. A. Connors. Phase solubility techni, The apparent stability constant of the KET- BCD compl, Using the approach of Higuchi and Connors, phase-solubility s, The phase solubility analysis described by Higuchi and, 2.3. Solubility Measurements. Phase-solubility studies of benzo, method described by Higuchi and Connors (1965). Excess amounts, If inclusion complexation were the only contribution, Sep 1, 2010 · HIGHLIGHTS Enhanced curcumin solubility up to 190, The phase solubility study was performed in water as per the report.